It would undoubtedly be difficult to live in complete isolation from people. Since, human's are social beings, it would be inevitably detrimental to physical and mental health, and even spiritual health, if you believe in that sort of thing. If there was no companion ship or communication, the person who is locked away may begin to show signs of cabin fever. As far as I understand it, cabin fever is the slow degeneration of mental saneness due to prolonged isolation and lack of human interaction. It would definitely be lonely and depressing.
I would definitely become depressed without any human interaction, maybe even lethally depressed. One of the most beautiful things about life, is that sacred bond we have with other human beings. It's pretty awesome that we are able to communicate our experiences and care and support each other as we journey through life. With life being hard sometimes, it is a truly beautiful thing to have the love and care of other people to work you through it. Love is a wonderful thing, whether it be familial love, friendly love, or romantic love. Without human interaction, there is no love. Without love, life seems almost pointless.
Your second paragraph is one of the best arguments for why isolation is detrimental that I've heard. Good work!
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