Living in isolation would be, obviously, very lonely. Humans are social creatures, and without any social interaction at all, it is like we are missing some part of ourselves. The amount of time it would take for being alone to change from tranquil to terrible varies from person to person, but there is always a point where solitude stops being pleasant.
Based on known cases of extreme solitude, especially "prairie madness," which is caused by circumstances similar to those of the Frome household, we can make reasonable assumptions about solitude's effect. Over extended periods, situations with little to no social contact lead to depression and anxiety. Individuals will withdraw from the few social situations they have, worsening the isolation, and violence and suicide are not uncommon. All in all, it is very unpleasant.
I think if I was in this situation, my introversion will allow me to last longer than others, but I could not go on forever. It is a rare breed that can survive isolation, and I am not one of them.
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